Alberto Botía
Guillermo Perez Moreno
Pablo Gil Sarrion
Mariano Sanchez Martínez
Arturo Perez Reverte
Celia Montalban
Angela Moreno
Pedro Alberto Cruz
Iker Casillas
David Villa
Spanish. Pamplona, Navarra
Spanish. Sevilla, Andalusia
Singer David Bisbal
Carmen Maura, actress
Soraya Saenz, Deputy Prime Minister
Spanish People:
Spanish Bullfighter Julio Benitez(Cordoba, Spain)
Michel Salgado(Galicia, Spain)
Maria Cotiello
Maria Cotiello
Maria Cotiello
Maria Cotiello
2010 FIBA World Championship
Genetic Structure of the Spanish Population
Gayan et al. (2010)
BMC Genomics
Background
Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.
Results
In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.
Conclusions
In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
Figure 6. PC results (marker subset B) for Spanish sample. Scatter plot of the top two Principal Components from the analysis of the Spanish sample, using SNP marker subset B which includes 102,850 SNPs (two-locus r2<0.8; Long-range LD regions excluded from analysis).
Figure 7. PC results (marker subset B) for European samples. Scatter plot of the top two Principal Components from the analysis of the Spanish sample and two European HapMap samples, using SNP marker subset B. HapMap sample acronyms stand for: CEU: Utah residents with ancestry from northern and western Europe; TSI: Toscani in Italy.
Figure 8. PC results (marker subset B) for Worldwide samples. Scatter plot of the 20 top two Principal Components from the analysis of the Spanish sample and multiple HapMap samples, using SNP marker subset B. HapMap sample acronyms stand for: European (CEU: Utah residents with ancestry from northern and western Europe; and TSI: Toscani in Italy), African (ASW: African ancestry from Southwest USA; LWK: Luhya in Webuye, Kenya; MKK: Maasai in Kinyawa, Kenya; YRI: Yoruba in Ibadan, Nigeria) and Asian ancestry (CHB: Han Chinese in Beijing, China; CHD: Chinese in Metropolitan Denver, Colorado; GIH: Gujarati Indians in Houston, Texas; JPT Japanese in Tokyo, Japan).
Figure 9. PC results (marker subset B) for Spanish sample over map of Spain. Results of the Principal Components analysis overlying the map of Spain, with recruiting centers marked with bigger circles (for clarity, only recruiting centers contributing more than 10% of the total sample size are shown).
http://www.biomedcentral.com/1471-2164/11/326/abstract
Autosomes
Y-Chromosome
mtDNA
http://s1.zetaboards.com/anthroscape/topic/3378695/1/#new
http://s1.zetaboards.com/anthroscape/topic/3786628/1/
